Hydrolyzed Fish Collagen - Average Nutritional Values
|Total Fat||0.0 grams|
|Saturated Fat||0.0 grams|
|Total Carbohydrates||0.0 grams|
|Vitamin A||0.0 iu/gram|
|Vitamin C||0.0 milligrams|
|Amino Acid||Residues/1000||Weight Percent|
* Essential amino acids. These are readily available in meat, poultry, eggs, fish, milk and cheese which are part of a balanced diet. Collagens are composed of amino acids and have the same Chemical Abstract Service number 68410-45-7 no matter if they come from fish, cattle, or pigs. The difference is that the amino acids are in slightly different percentages.
- Typical Certificate of Analysis.
- Manufactured in Canada.
- Complies with USP1 for gelatin.
|Manufacture Date:||AS SHOWN||July 23,2018|
|Expiration Date:||3 YEARS FROM MANF. DATE||July 23,2021|
|Color:||WHITE TO OFF WHITE||OK|
|Odor:||NO OBJECTIONAL ODOR||OK|
|pH of 10% Solution||5.0 - 6.5||6.0|
|Visc 10% Sol@30°C||1 - 3 cSt||2.0 cSt|
|Loss On Drying||MAX. 8%||5.0%|
|Nitrogen Content||AS SHOWN||17.1%|
|Total Inorganics (ASH)||MAX. 2.0%||0.3%|
|Heavy Metals||< 10 ppm||0.7 ppm|
|Arsenic||< 0.8 ppm||0.07 ppm|
|Cadmium||< 0.5 ppm||< 0.004 ppm|
|Chromium||< 10 ppm||0.2 ppm|
|Copper||< 30 ppm||0.5 ppm|
|Iron||< 10 ppm||4.0 ppm|
|Lead||< 1.0 ppm||< 0.004 ppm|
|Mercury||< 0.1 ppm||< 0.02 ppm|
|Zinc||&l0 ppt; 50 ppm||0.12 ppm|
|Hydrogen Peroxide||NOT USED IN PROCESS||0 ppm|
|Sulfites/Sulfer Dioxide||NOT USED IN PROCESS||0 ppm|
|Aerobic Bacteria Count||MAX. 1000/g||<10/g|
|Yeast and Mold Count||MAX. 100/g||<10/g|
|Enterobacteria||NEGATIVE IN 1 g||PASS|
|Staphylococcus A.||NEGATIVE IN 1 g||PASS|
|Pseudomonas A.||NEGATIVE IN 10 g||PASS|
|E. Coli||NEGATIVE IN 25 g||PASS|
|Salmonella||NEGATIVE IN 25 g||PASS|
1. USP: The United States Pharmacopeia defines official standards of purity and is recognized by federal law as the official U.S. compendia for dietary supplements
Fish Gelatin and Hydrolyzed Fish Collagen – Statement on Allergenicity
While milligrams of fish are known to cause allergic reactions in some individuals, fish gelatin did not cause any observable reactions in a hospital supervised test with known cod fish allergic patients who ingested a cumulative amount of 14.61 grams.
A Double Blinded Placebo Controlled Food Challenge (DBPCFC)1 was published in the Food and Chemical Toxicology journal. In this test, Norland Dried Fish Gelatin was ingested by 30 patients who were known to be allergic to cod fish. The cod fish skin is the major skin used for producing Norland Fish Gelatin and Hydrolyzed Fish Collagen. All are manufactured exclusively by Kenney & Ross Ltd. in Nova Scotia, Canada.
A mild, non-observable reaction occurred with three patients. One experienced a reaction to the gelatin and the other two experienced reactions to the placebo. All 30 patients ingested a total of 14.61 grams of Fish Gelatin without any observable reactions by the doctor.
The mentioned patient was tested twice and had a mild, subjective (non-observable) reaction of “an irritation in the throat” at a cumulative dose of 7.61 grams. It is interesting to note that the same patient ingested the higher cumulative dose of 14.61 grams with no reaction. We consider the patient's reaction to be a false positive since most allergic reactions increase in severity with increased exposure and the gelatin was later tested as having no detectable allergens. None of the patients experienced any reaction to 3.61 grams.
This hospital supervised test was performed by doctors and arranged with the assistance of the Food Allergy Resource and Research Program (FARRP) at the University of Nebraska.
The major allergen in fish is a water soluble protein called parvalbumin. The manufacturing process uses massive quantities of water to clean the skins for all Norland Fish Gelatins and Hydrolyzed Fish Collagen which are Type A gelatins.
This removes the water soluble allergens from the skin and significantly reduces the possibility ofan allergic reaction. In a separate DBPCFC2, raw cod fish meat was ingested by 10 known cod fish allergic patients. One of the ten reacted after ingesting 6 milligrams and 6 more had observable reactions to quantities up to 6.6 grams.
Even though the extraction processes are different, the Norland Dried Fish Gelatin, High Molecular Weight Fish Gelatin and Hydrolyzed Fish Collagen all start with the same thorough washing procedure. This allows the water soluble allergens to be removed regardless of which manufacturing process is used.
Since January 2008, Kenney & Ross Ltd. has used an independent, accredited laboratory to test every Hydrolyzed Fish Collagen lot using a validated ELISA3 developed from purified cod parvalbumin and sensitive to 0.02 ppm. In all assays, there is no detectable allergen. The gelatin used for the DBPCFC1 was tested, also with the same result of no detectable allergen. As a sensitivity comparison, commercial ELISAs have a limit of sensitivity of 1 – 2.5 ppm for peanuts.
Based on the data presented above, we consider it to be unlikely that Hydrolyzed Fish Collagen will trigger an adverse allergenic reaction in individuals with fish allergy. Even so, fish allergic consumers should consult their doctors prior to ingesting the Hydrolyzed Fish Collagen.
- Hansen TK, Poulsen LK, Skov PS, Hefle SL, Hlywka JJ, Taylor SL, Bindslev-Jensen U, Bindslev-Jensen C, A randomized, double-blinded, placebo-controlled oral challenge study to evaluate the allergenicity of commercial, food-grade fish gelatin. Food and Chemical Toxicology 42(2004), 2037-2044
- Hansen TK, Bindslev-Jensen C. Codfish allergy in adults. Allergy 1992: 47: 610-617
- Bremer M, Selecting a Suitable Food Allergen Detection Method, Food Safety Magazine, June/July 2009, 16-19, 53 http://www.foodsafetymag-digital.com/foodsafetymag/20090607/?folio=16